Hydrolysis of Bis (p-hydroxyphenyl) pyridyl-2-methane Disulfate. I. Presence of Arylsulfatase and Laxative Activity

Abstract

The laxative action of bis (p-hydroxyphenyl) pyridyl-2-methane disulfate is considered to be dependent on the formation of the free phenolic compound, bis (p-hydroxyphenyl)-pyridyl-2-methane by hydrolysis. Therefore, the activity of the parent compound as a laxative must be governed by arylsulfatase activity in the human intestine. When examinations of human feces were made, arylsulfatase activity in the intestine was detected, and about 98% of the samples were shown to be positive. Validity of the fecal arylsulfatase test in the test population might be supported by the liquefaction test of rat feces with the injection of the parent compound into duodenum.