Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Peptides. LX. Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Bovine Adrenocorticotropic Hormone
小山 要河谷 紘樹矢島 治明藤野 政彦西村 紀
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1976 年 24 巻 9 号 p. 2106-2111

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The nonatriacontapeptide corresponding to the newly revised amino acid sequence of bovine adrenocorticotropic hormone was synthesized by successive condensation of 3 peptide fragments ; Z(OMe)-(15-19)-OH, Z (OMe)-(11-14)-OH and Z-(1-10)-OH, with H-(20-39)-OBzl, a synthetic intermediate of bovine type corticotropin-like intermediate lobe peptide. The synthetic peptide exhibited the in vivo steroidogenetic activity of 93.8 IU/mg.

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© The Pharmaceutical Society of Japan
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