Abstract
Segmental difference in the transmucosal fluid movement and its effect on the drug absorption was studied with sulfanilamide, sulfisoxazole and metoclopramide. The segments investigated were stomach, duodenum, jejunum, ileum and colon, and the ligation method was employed in the experiment of the stomach, and the reat of the segments were investigated by the simultaneous four in situ recirculation perfusions method which was devised originally in our laboratories. The results revealed that the absorption of the drugs in the stomach was not affected by the transmucosal fluid movement, while large volume of fluid secretion was observed. However, the drug absorption in the rest of the segments was affected in some extent by the fluid movement. Segmental differences in the absorption of these three drugs were also elucidated. Concerning the glucose effect, it was revealed that the effect was localized only in the upper part of the small intestine.
