Synthesis of 3, 3'-Biquinazoline-4, 4'-diones and 1, 3, 4-Oxadiazoles from Isatoic Anhydride
キーワード:
polyphosphoric acid
1977 年 25 巻 10 号 p. 2713-2717
詳細
1977 年 25 巻 10 号 p. 2713-2717
Treatment of isatoic anhydrides with hydrazine hydrate gave 1, 2-bis-(o-aminobenzoyl)-hydrazines (IIa-c). The reaction of IIa, b with ethoxymethylenemalononitrile, ethyl ethoxymethylenecyanoacetate or triethyl orthoformate afforded new 3, 3'-bisquinazoline-4, 4'-diones (IIIa, b and IVa-d) in good yields. On the other hand, the reaction of IIa-c with polyphosphoric acid furnished 2, 5-diaryl-1, 3, 4-oxadiazole derivatives in high yields.
