Polycyclic N-Hetero Compounds. XVII. Reactions of Heterocyclic Active Methyl Group with Formamide or Trisformylaminomethane

Abstract

Pyrimidine formation from active methyl group on heterocycles is described. 2-Methyl-pyridine (I), -quinoline (III), -pyrazine (IX), -benzothiazole (XX), 2, 4-dimethylquinoline (VII), and-thiazole (XIII) were successful in pyrimidine formation. 2-Methylimidazole (XI), -benzimidazole (XV), -benzoxazole (XVI), and 2, 4-dimethyloxazole (XII) were unsuccessful. Compound (III) gave pyrazine (V) and pyridine (VI) derivatives and pyridine formation occurred also in XX.