Protein Binding of Sulfonylureas. I. Interaction of Some Substituted Benzenesulfonyl Propylureas to Bovine Serum Albumin

抄録

Binding affinities of five 4-substituted benzenesulfonyl propylureas to bovine serum albumin (BSA) were investigated by equilibrium dialysis method. Those of chlorpropamide (CPU) to BSA was also investigated by dynamic dialysis method using ³⁵S labelled CPU. Results of both methods agreed very well. Binding paramethers of these compounds to BSA were obtained assuming that there were two classes of binding sites. CPU and 4-iodobenzenesulfonyl propylurea were bound to BSA stronger than benzenesulfonyl, p-toluenesulfonyl and 4-aminobenzenesulfonyl propylureas with regard to the primary binding site.