Effect of Antitumor Alkylating Agents on Semiconservative and Unscheduled DNA Syntheses in Rat Ascites Hepatoma Cells

Abstract

The effects of several compounds on ultraviolet light-induced unscheduled desoxyribonucleic acid (DNA) synthesis and semiconservative DNA synthesis were examined in rat ascites hepatoma, AH-44 cells. The compounds used did not inhibit unscheduled DNA synthesis as much as or more than semiconservative DNA synthesis. Only improsulfan had a tendency to inhibit unscheduled DNA synthesis to a greater extent than semiconservative DNA synthesis.