Author's Organization：Research Institute, Daiichi Seiyaku Co., Ltd. Research Institute, Daiichi Seiyaku Co., Ltd. Research Institute, Daiichi Seiyaku Co., Ltd. Research Institute, Daiichi Seiyaku Co., Ltd. Research Institute, Daiichi Seiyaku Co., Ltd.
The metabolic pathways of budralazine were studied in vivo and in vitro experiments and characterized as follows ; 1) 3-methyl-s-triazolo [3, 4-a] phthalazine (M-1), one of the major metabolites of budralazine, was mainly biotransformed via 1-hydrazinophthalazine. 2) s-triazolo [3, 4-a] phthalazine (M-3) was also biotransformed via 1-hydrazinophthalazine. 3) Experiments using liver preparations of rat were also discussed briefly.
