Preparation of a Specific Antibody to Methamphetamine

SEIICHI INAYAMA; YUKIKO TOKUNAGA; EIKICHI HOSOYA; TERUO NAKADATE; TETSUKICHI NIWAGUCHI; KIMIKO AOKI; SHOJI SAITO

doi:10.1248/cpb.25.838

SEIICHI INAYAMA, YUKIKO TOKUNAGA, EIKICHI HOSOYA, TERUO NAKADATE, TETSUKICHI NIWAGUCHI, KIMIKO AOKI, SHOJI SAITO

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Keywords: ouchterlony method

JOURNAL FREE ACCESS

1977 Volume 25 Issue 4 Pages 838-840

DOI https://doi.org/10.1248/cpb.25.838

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Abstract

N-Carboxymethylmethamphetamine (III) has been synthesized directly from methamphetamine (I) and through a new route starting from ephedrine (IV). This new hapten was conjugated with BSA and the antiserum for I was prepared by immunization of rabbits with the conjugate (VIII). The production of the antibody for I was confirmed by the ring test and Ouchterlony method.

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