抄録
Dissolution curves of colchicine in water, carbon tetrachloride, and benzene revealed that solvates are formed after initial dissolution of ansolvate with a resultant decrease in concentration in solution. An aqueous solubility-temperature profile exhibited a minimum in 25-45° range. Addition of trichloroethanol and chloroform to benzene resulted in increase in benzene/water partition coefficient of colchicine. Benzene/water and carbon tetrachloride/water partition coefficients were greater at higher temperature. Salt effects on benzene/water partition coefficient followed the Hofmeister series and the Setshenow relationship.
