Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on the β-Lysine Peptide. IV. Preparation of Semi-synthetic Racemomycins and Their Antimicrobial Activities
YOSUKE SAWADA, HYOZO TANIYAMA
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Keywords: ε-amino function
JOURNAL FREE ACCESS

1977 Volume 25 Issue 6 Pages 1302-1305

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Abstract
Racemomycin-C was semi-synthesized from racemomycin-A by condensation with diZ-β-lysine-OSU followed by catalytic hydrogenation. Racemomycins B, D and E were also prepared in the similar manner. Among these antibiotics, racemomycin-B containing three β-lysine residues in one molecule showed the strongest antibacterial activity against B. subtilis.
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© The Pharmaceutical Society of Japan
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