An Improved Procedure for the Synthesis of 1-Alkyladenines : Removal of the Ribofuranosyl Group from 1-Benzyl-, 1-(3-Methyl-2-butenyl)-, and 1-Allyladenosine Hydrobromide in Acetic Acid

Abstract

1-Benzyl- (IIIa), 1-(3-methyl-2-butenyl)-(IIIb), and 1-allyladenine (IIIc) were prepared in 77, % 44%, and 69% yield, respectively, by alkylation of adenosine (I) followed by heating the resulting 1-substituted adenosine hydrobromides (IIa, b, c) in acetic acid.