Studies on the Heterocyclic Compounds. XX. The Reaction of 4-Cyano-3, 6-dichloropyridazine with Amines

Abstract

4-Cyano-3, 6-dichloropyridazine (II) was treated with primary amines in methanol under mild condition (stirring at 0-5°) to give neither the corresponding 3- nor 6-amino derivatives but the corresponding 5-amino derivatives (XVd-m) resulting from nuclear amination. However, when compound II was treated with secondary amines, the corresponding 3- or 6-amino derivatives were obtained.