Platelet Aggregation Inhibitors. VIII. 2-Thioadenine Derivatives

Abstract

A series of S-substituted 2-thioadenines (VII) and S, 9-di-substituted 2-thioadenines (VIII) were prepared by direct alkylation of 2-thioadenine (IV). Among the compounds synthesized, 2-cyclopentylthio-9-methyladenine (VIII₇), 2-cyclopentylthio-9-cyclopentyl-adenine (VIII₂₀) and 2-[2-(4-benzylpiperazino) ethyl] thio-9-[2-(4-benzylpiperazino) ethyl]-adenine (VIII₂₂) were inhibitory against adenosine 5'-diphosphate induced platelet aggregation but these were less potent than adenosine.