Studies on the Heterocyclic Compounds. XXI. A New Alkylation of Pyridazines with Nitromethane and Nitroethane

Abstract

Pyridazine derivatives (I, III, V, VII, IX, XI, XIII, XV, XVII, and XIX) were treated with nitromethane and nitroethane in the presence of a basic catalyst to give the corresponding 5-methyl (IIa, IVa, VIa, VIIIa, Xa, XIIa, XIVa, XVIa, XVIIIa, and XXa) and 5-ethyl derivatives (IVb, VIb, VIIIb, Xb, XIIb, XIVb, XVIb, and XVIIIb). Namely, in these reactions nuclear alkylation occurred instead of nitroalkylation.