Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Selective O-Benzoylation in Aminoglycoside Antibiotics
HIROMICHI SAEKI, TERUO HAYASHI, YOSHIKAZU SHIMADA, NORIKO TAKEDA, EIJI OHKI
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Keywords: kanamycin
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1977 Volume 25 Issue 8 Pages 2089-2097

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Abstract
It was shown that the 3'and 4'hydroxy groups of N-protected butirosin or kanamycin derivatives resist benzoylation in an aqueous medium, furnishing an effective method for chemical modifications of these antibiotics.
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© The Pharmaceutical Society of Japan
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