Abstract
Naphthalene-sodium reaction of 3, 4-dimesylates of N-protected 2, 6-diamino-2, 6-dideoxy-α-D-glycosides (1a, 1b) resulted in a good yield of 3-eno compounds (2a, 2b). Application of this anion-radical reaction to butirosin 3', 4'-dimesylate (3) gave 3', 4'-dideoxy-3'-one butirosin A (4a) which shows a broad inhibitory activity against bacteria which are both sensitive and resistant to butirosin. Kanamycin 3', 4'-dimesylate (5a) also analogously gave a 3'-eno derivative (6).
