Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Study of Crystalline Drugs by Means of Polarizing Microscope. I. Identification of Polymorphic or Solvated Forms in Thiamine Hydrochloride, Bromvalerylurea and Ampicillin
ATSUSHI WATANABEYUMIKO TANAKAYOKO TANAKA
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Keywords: immersion method
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1977 Volume 25 Issue 9 Pages 2239-2243

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Abstract
The microscopic study of crystalline substances using a polarizing microscope and the immersion media was shown to have an advantage of simple and rapid identification of drugs, especially in polymorphs or solvates. Examples of the application of this technique were given for four crystal forms of thiamine hydrochloride, two forms of each bromvalerylurea and ampicillin. The accuracy and reproducibility of the measured refractive indices are discussed with its relation to crystal habit.
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© The Pharmaceutical Society of Japan
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