Abstract
Response of gastric acid secretion to benzyloxycarbonyl-Trp-Met-Asp-Phe-NH2 (tetragastrin) before and after perfusion of phenolic acids and related compounds was examined in the rat. Tannic acid and gallic acid inhibited the response to tetragastrin after perfusion of these compounds. But protocatechuic acid, p-hydroxybenzoic acid, salicylic acid, and aspirin stimulated the response to tetragastrin, and sometimes enhanced the basal acid secretion. Possible mechanism of ulcerative action of aspirin is discussed.
