Drug Responses of Canine Trachea, Bronchus and Bronchiole

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Effects of acetylcholine, pilocarpine, histamine, 5-hydroxytryptamine and nicotine on the isolated canine trachea, bronchus and bronchiole were investigated. In addition, Schultz-Dale test to Ascaris suum antigen on these airway smooth muscle preparations was attempted. Acetylcholine had a strong contractile effect on the trachea, bronchus and bronchiole, whereas large concentrations of histamine and nicotine were necessary to contract these preparations. Histamine was suggested to produce a stronger constriction of the peripheral airways like bronchioles. Pilocarpine showed a selective and remarkable contraction of bronchus. Schultz-Dale phenomenon to Ascaris antigen failed to be demonstrated on the airway preparations.