Isolation and Structure of Antipeptic Ulcer Diterpene from Thai Medicinal Plant

AKIRA OGISO; EIICHI KITAZAWA; MASAAKI KURABAYASHI; AIYA SATO; SHUJI TAKAHASHI; HIROSHI NOGUCHI; HARUMITSU KUWANO; SHINSAKU KOBAYASHI; HIROSHI MISHIMA

doi:10.1248/cpb.26.3117

AKIRA OGISO, EIICHI KITAZAWA, MASAAKI KURABAYASHI, AIYA SATO, SHUJI TAKAHASHI, HIROSHI NOGUCHI, HARUMITSU KUWANO, SHINSAKU KOBAYASHI, HIROSHI MISHIMA

Author information

AKIRA OGISO
EIICHI KITAZAWA
MASAAKI KURABAYASHI
AIYA SATO
SHUJI TAKAHASHI
HIROSHI NOGUCHI
HARUMITSU KUWANO
SHINSAKU KOBAYASHI
HIROSHI MISHIMA
Author's Organization：
Central Research Laboratories, Sankyo Co., Ltd.
Central Research Laboratories, Sankyo Co., Ltd.
Central Research Laboratories, Sankyo Co., Ltd.
Central Research Laboratories, Sankyo Co., Ltd.
Central Research Laboratories, Sankyo Co., Ltd.
Central Research Laboratories, Sankyo Co., Ltd.
Central Research Laboratories, Sankyo Co., Ltd.
Central Research Laboratories, Sankyo Co., Ltd.
Central Research Laboratories, Sankyo Co., Ltd.

Keywords: antipeptic ulcer

JOURNAL FREE ACCESS

1978 Volume 26 Issue 10 Pages 3117-3123

DOI https://doi.org/10.1248/cpb.26.3117

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Abstract

A potent antipeptic ulcer substance, acyclic diterpene alcohol, was isolated from a Thai medicinal plant identified with Croton sublyratus KURZ. The structure was determined by the spectral data and stereospecific synthesis to be (E, Z, E)-7-hydroxymethyl-3, 11, 15-trimethyl-2, 6, 10, 14-hexadecatetraen-1-ol.

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