Author's Organization：Faculty of Pharmaceutical Sciences, University of Tokyo Faculty of Pharmaceutical Sciences, University of Tokyo Faculty of Pharmaceutical Sciences, University of Tokyo
An aconite alkaloid, kobusine (1) was converted to a C14-C20 bond cleaved derivative (12) by a novel fragmentation reaction via a chloramine (11). Possible mechanisms were discussed in which participation of anionic nitrogen was proposed. The C14-C20 bond regeneration in compound (12) was also accomplished by an intramolecular Grignard type reaction.
