Abstract
According to the previously proposed model for drug distribution in the body, the apparent volumes of distribution (Vd') of basic drugs with high apparent partition coefficients (P') were related to the blood plasma volume, the other non-lipid space, and the lipid space. The logarithm of Vd' values for basic drugs with P' of 3.2×100-6.7×102 had good correlation (r=0.937) with the logarithm of P'values. The relationship between Vd' and P' was estimated in the region of both low and high P'. The comparison of the result with the observed values indicated that the proposed model was considerably satisfactory, but that there were some other factors which fluctuated the values of Vd'.
