1978 年 26 巻 2 号 p. 605-610
Choline esters of peptides related to tetragastrin, Z-Asp (OBut)-Phe-OCh+ Br-(XII), Z-Met-Asp (OBut)-Phe-OCh+ Br-(XIII), Z-Trp-Met-Asp(OBut)-Phe-OCh+ Br-(XIV), and BOC-Trp-Met-Asp (OBut)-Phe-OCh+ Br- (XV) were synthesized by the condensation of N-protected peptides, (VI), (VII), (VIII), and (IX), with β-dimethylaminoethyl bromide followed by methylation with methyl bromide. Selective removal of the protective groups from the above peptide choline esters was achieved by conventional acid treatment under mild conditions.