1, 2, 4-Triazoles. VIII. Synthesis and Antimicrobial Activity of 3-Alkylthio-5-pyridyl-1, 2, 4-triazoles and Related Compounds

Abstract

Series of 3-alkylthio-5-(2-pyridyl)-1, 2, 4-triazoles and 1-picolinoyl-S-alkylisothiosemi-carbazides were prepared and their antimicrobial activities were tested. Of the twenty-two compounds synthesized and screened in vitro, 3-pentylthio-5-(2-pyridyl)-1, 2, 4-triazole, 1-picolinoyl-S-butylisothiosemicarbazide, 1-picolinoyl-S-pentylisothiosemicarbazide, and 1-picolinoyl-S-hexylisothiosemicarbazide were the most active against M. tuberculosis H₃₇Rv.