The Chemistry of Aminoglycoside Antibiotics from Pseudomonas fluorescence. I. Isolation, Characterization and Partial Structure of P-2563 (P) (Sorbistin A₁) and P-2563 (A) (Sorbistin B)

Abstract

Two aminoglycoside antibiotics active against Gram-positive and -negative bacteria, P-2563 (P) (1) and P-2563 (A) (2) were isolated from a culture broth of Pseudomonas fluorescence P-2563. It was found that 1 (C₁₅H₃₁N₃O₉) and 2 (C₁₄H₂₉N₃O₉) are acylaminoglycoside having the same new aminopolyol structure in their molecules. 1 and 2 showed low order of acute toxicity in mice.