Synthesis of the Dodecapeptide Amide corresponding to the Entire Amino Acid Sequence of Granuliberin-R, a New Frog Skin Peptide from Rana rugosa

Abstract

Amino acid sequence of a new frog skin peptide named granuliberin-R, H-Phe-Gly-Phe-Leu-Pro-Ile-Tyr-Arg-Arg-Pro-Ala-Ser-NH₂, was assessed by two conventional ways of synthesis ; the one by the methanesulphonic acid procedure and the other by the catalytic hydrogenation procedure at the final deprotection steps.