Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
The Base-catalyzed Deuteration of Hydrogen in Methyl Group substituted at 3-Position of Pyrazolone Ring
TSUYOSHI GOROMARU, ATSUKO NODA
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Keywords: tracer
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1978 Volume 26 Issue 7 Pages 2258-2261

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Abstract
A simple method for labeling methyl group with deuterium at 3-position of pyrazolone ring was established. Trideuterium labeled aminopyrine obtained by the present method did not indicate the isotope effect. It is available for a tracer as well as an internal standard on gas chromatography-mass spectrometry.
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© The Pharmaceutical Society of Japan
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