Studies on the Constituents of Buddleja Species. I. Structures of Buddledin A and B, Two New Toxic Sesquiterpenes from Buddleja davidii FRANCH.

Abstract

Two new piscicidal sesquiterpenes, buddledin A (1) and B (2), have been isolated from the root bark of Buddleja davidii FRANCH. These structures have been deduced on the basis of spectroscopic and chemical evidences, and confirmed by X-ray analysis of the bromohydrin (8). The absolute configuration was determined by the applications of benzoate rule and dibenzoate chirality rule. Buddledin A and B are the first examples of toxic compounds possessing the caryophyllene skeleton.