Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Effect of Pyrazolone Derivatives on the Critical Micelle Concentration of Ionic Surfactants
YASUNORI MORIMOTOTOKIKO IZUMITAKAICHI ARITA
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1978 Volume 26 Issue 8 Pages 2585-2588

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Abstract
Effect of pyrazolone derivatives on the critical micelle concentration (cmc) of surfactants was investigated by using ionic surfactants which were sodium dodecyl sulfate (SDS) and dodecyl N-dimethylethylammonium bromide (DDAB). It is shown that antipyrine and 4-aminoantipyrine which are very water soluble is in breaking up micelles of SDS and DDAB. However, addition of phenylbutazone which is very slightly soluble in water results in increase in stability of the micelles. It is presumed from these results that the affinity of these additive for water plays an important role in stability of the micelles.
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© The Pharmaceutical Society of Japan
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