A New Synthesis of Pyrimido [4, 5-b] quinoline-2, 4 (1H, 3H) diones (5-Deazaalloxazines) by Oxidative Cyclization of Aryl-bis (6-amino-1, 3-dimethyluracil-5-yl)-methanes with Diethyl Azodicarboxylate

Abstract

Treatment of aryl-bis (6-amino-1, 3-dimethyluracil-5-yl) methanes, which were prepared by the condensation of 6-amino-1, 3-dimethyluracil with aryl aldehydes, with diethyl azodicarboxylate in the presence of sulfolane led to the formation of the corresponding 1, 3-dimethylpyrimido [4, 5-b] quinoline-2, 4 (1H, 3H) diones (1, 3-dimethyl-5-deazaalloxazines).