Author's Organization:School of Pharmaceutical Sciences, Kitasato University School of Pharmaceutical Sciences, Kitasato University School of Pharmaceutical Sciences, Kitasato University
The lactone (5) reacts with methylamine to afford the methylaminophthalide (6). On the basis of the reactions of 6 and related compounds, the spiro lactam (14) is suggested to be an intermediate in the formation of 6 from 5.