Atropine-like Activities of 2-Substituted 5-Piperidinomethylfuran Derivatives

抄録

2-Substituted 5-piperidinomethylfuran derivatives were synthesized and their atropine-like and antihistamine activities were tested. The pA₂ values of the tested compounds for atropine-like activity were 7.50 to 5.21, less than that for atropine. The antihistamine activities (pA₂ values : 6.64 to 4.31) were much less than that of chlorpheniramine. Methylation of piperidine essentially did not affect the atropine-like activities but considerably decreased both the competitive and noncompetitive antihistamine activities.