Abstract
Sulfamethizole was pulverized by recrystallization from glycols or their derivatives, and correlation of difference in the degree of pulverization with the solvent was studied. Crystalline properties of the pulverized crystals of sulfamethizole thus obtained were also studied. The degree of pulverization of sulfamethizole by recrystallization from glycols and their derivatives decreased with increase in the number of carbon atoms in the hydrophobic chain of these solvents. When the pulverized sulfamethizole were examined by IR, X-ray diffraction, and DSC-TG, two kinds of hydrate and one kind of anhydride were detected. The form I (anhydride) was transformed into form III (hydrate ; 1 mol H2O) in the artificial gastric juice of 37°, but not in water.
