The Studies on the Active Peptide in the Skin of Rana rugosa. II. The Structure of Ranatensin-R, the New Ranatensin Analogue, and Granuliberin-R, the New Mast Cell Degranulating Peptide

Abstract

The skin of Rana rugosa contained ranatensin-R, a new analogous peptide to ranatensin. Ranatensin-R is heptadecapeptide amide which is a longest analogue of ranatensin ever isolated from the frog skin. Granuliberin-R, dodecapeptide amide, was obtained from the same ranatensin-R fraction during the separation process. The peptide is a new type of amphibian skin peptide which acts on the rat peritoneal mast cell to liberate granules and histamine from the cells.