Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Dogfish Adrenocorticotropic Hormone (Squalus acantias)

KENJI OKAMOTO; KOICHI YASUMURA; SHINICHI SHIMAMURA; MASUHISA NAKAMURA; AKIRA TANAKA; HARUAKI YAJIMA

doi:10.1248/cpb.27.499

岡本憲治, 安村貢一, 島村真一, 中村益久, 田中明, 矢島治明

著者情報

キーワード: in vivo steroidogenetic activity

ジャーナルフリー

1979 年 27 巻 2 号 p. 499-507

DOI https://doi.org/10.1248/cpb.27.499

詳細

抄録

The nonatriacontapeptide corresponding to the entrie amino acid sequence of dogfish adrenocorticotropic hormone was synthesized by successive condensations of three peptide fragments ; Z (OMe)-(15-19)-OH, Z (OMe)-(11-14)-NHNH₂ and Z-(1-10)-OH, with H-(20-39)-OBzl, a synthetic intermediate of dogfish corticotropin-like intermediate lobe peptide. The synthetic peptide exhibited the in vivo steroidogenetic activity of 21.3 IU/mg.

責任著者(Corresponding author)

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