Studies on the Constituents of Asclepiadaceae Plants. XLV. On the Components of Metaplexis japonica MAKINO. VI. The Structures of 7-Oxygenated-Pregnane Derivatives

Abstract

The structures of three new polyoxypregnane derivatives, dibenzoylgagaimol, gagaimol-7-methylether, and 7β-methoxysarcostin, all of which were isolated from the root of Metaplexis japonica MAKINO, are shown to be I, II, and III, respectively. These three compounds are the first example of polyoxypregnane derivatives which have been obtained from the Asclepiadaceae plants, and shown to have an oxygen functional group at the 7-position.