Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Gas-Liquid Chromatography Separative Determination of 4'-Chloro-5-methoxy-3-biphenylylacetic Acid and Its Metabolites in Urine
MAKOTO SUGIYAMA, AKIRA MORINO, SHOGO IZUMI
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Keywords: derivatization
JOURNAL FREE ACCESS

1979 Volume 27 Issue 2 Pages 557-563

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Abstract
The amounts of 4'-Chloro-5-methoxy-3-biphenylylacetic acid (DKA-9) and its metabolites (DKA-9G, DKA-24, DKA-24G, DKA-24OG and DKA-24S, see Chart 1) in human urine could be determined separately by measuring the amounts of DKA-9 and DKA-24 generated after hydrolizing under various conditions with gas-liquid chromatography.
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© The Pharmaceutical Society of Japan
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