Antineoplastic Activity of Platinum Complexes of trans-(dl)-1, 2-Cyclopentanediamine

Abstract

Dichloro-trans-(dl)-1, 2-cyclopentanediamineplatinum (II) and its derivatives, mixed ligand complexes with oxalato, malonato, or sulfato, were synthesized and tested against Leukemia P-388. All of these complexes have high antineoplastic activity. Among them sulfato-trans-(dl)-1, 2-cyclopentanediamine revealed a very high therapeutic index and is more effective than the corresponding complex of 1, 2-cyclohexanediamine.