Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Synthesis of Two Peptides corresponding to α-Endorphin and γ-Endorphin by the Methanesulfonic Acid Deprotecting Procedure
MINORU KUBOTA, TADAMASA HIRAYAMA, OSAMU NAGASE, HARUAKI YAJIMA
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Keywords: analgesic effect
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1979 Volume 27 Issue 4 Pages 1050-1054

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Abstract
Methanesulfonic acid was employed as a deprotecting reagent for the syntheses of the hexadecapeptide and the heptadecapeptide corresponding to α-endorphin and γ-endorphin. Their analgesic potencies were 0.021 and 0.013 relative to that of morphin respectively.
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© The Pharmaceutical Society of Japan
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