Abstract
To isolate an intermediate, cyclodextrin salicylate, the reactions of phenyl salicylates with cyclodextrin were kinetically investigated in alkaline 22% acetonitrile solution. Even in the alkaline solution, the formation and accumulation of cyclodextrin salicylate was confirmed during the course of the reactions. The possible mechanism was discussed. The deacylation rate of cyclodextrin salicylate was considerably small compared with the uncatalyzed hydrolysis rates of phenyl salicylates and that of the acylation of cyclodextrin.
