著者所属:Institute for Biological Science, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd. Institute for Biological Science, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.
Carbocyclic analogs of captopril (SQ-14225, I), an angiotensin-converting enzyme (ACE) inhibitor, were synthesized starting from methyl cyclopentenoate (III) in order to examine their inhibitory activity of ACE.