Synthesis of Pyrazolone Derivatives. XXXV. Synthetic and Pharmacological Studies on Some (4S, 7R)-4, 7-Methano-1H-indazoles

SHINICHI NAGAI; NORIICHI ODA; ISOO ITO; YOSHIHISA KUDO

doi:10.1248/cpb.27.1764

Synthesis of Pyrazolone Derivatives. XXXV. Synthetic and Pharmacological Studies on Some (4S, 7R)-4, 7-Methano-1H-indazoles

永井慎一, 織田範一, 伊藤磯雄, 工藤佳久

著者情報

キーワード: contracture of the muscle

ジャーナルフリー

1979 年 27 巻 8 号 p. 1764-1770

DOI https://doi.org/10.1248/cpb.27.1764

詳細

抄録

Treatment of (1R, 4S)-2-oxobornaneglyoxylic acid (1) with substituted hydrazines gave (4S, 7R)-1-substituted-4, 7-methano-1H-indazole-3-carboxylic acids (2). (4S, 7R)-1-Phenyl-4, 7-methanoindazole-3-ol (8) was synthesized by two independent synthetic routes. (4S, 7R)-N-Substituted-4, 7-methanoindazole-3-carboxamides (4a, b) were tested on an isolated nerve-muscle preparation of bullfrog. Compound 4b caused marked contracture of the muscle.

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