Applications of a Carbon Dioxide Selective Electrode. I. Determination of Meprobamate by Decomposition with Alkali

Abstract

Meprobamate decomposes into NH₃, Na₂CO₃, and a diol compound on heating in 1N NaOH, and CO₂ evolved at pH 4.8 can be determined by the use of a CO₂ selective electrode without separation from the decomposition solution. A linear calibration curve was obtained within the concentration range of 1×10^-4-2.5×10^-2M meprobamate. Carbon dioxide in water does significantly influence the potential response, so that this method requires the use of distilled water pre-treated by boiling.