Abstract
A common conformation was assumed to be involved in the potent muscarinic activities of L (+)-muscarine, acetylcholine, and (+)-trans-2S-acetoxycyclopropyl-1S-trimethyl-ammonium. The conformation of other muscarinic agents was also considered from this point of view ; three types of quaternary salts having semi-rigid piperidine ring structures which satisfy the hypothetical requirements were synthesized, and their muscarinic activities were examined. These synthetic compounds showed selective muscarinic activity.
