Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Identification of Hydrazine derived from Hydralazine in Experimental Animals
野田 敦子松山 賢治顔 淑恵尾辻 望井口 定男野田 浩司
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1979 年 27 巻 8 号 p. 1938-1941

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The liberation of hydrazine from hydralazine was demonstrated in rabbit urine, in rat plasma and in a rat enzyme system. The identification of hydrazine in rabbit urine was performed by comparison of the gas chromatogram and mass spectrum of its benzalazine derivative with those of an authentic sample. Small amounts of hydrazine extracted from rat plasma and the rat enzyme system were detected by mass fragmentography using 15N-hydrazine.
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© The Pharmaceutical Society of Japan
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