Synthesis and Effects of Two Peptide Fragments of Thymopoietin II on E-Rosette Forming Cells in the Uremic State

Abstract

Two peptides, H-Lys-Asp-Val-Tyr-Val-Gln-Leu-Tyr-Leu-OH and H-Arg-Lys-Asp-Val-Tyr-Val-Gln-Leu-Tyr-Leu-OH (fragment of thymopoietin II), were synthesized in a conventional manner utilizing the hydrogen flluoride procedure, and were tested to determine their effects on E-rosette forming cells in the uremic state. The synthetic decapeptide increased E-rosette forming capacity in the presence of uremic serum. The synthetic nonapeptide had no effect on the E-rosette formation inhibiting activity of uremic serum.