Studies on Pyrimidine Derivatives. XV. Homolytic Acylation and Amidation of Simply Substituted Pyrimidines

抄録

The reaction of 2, 6-disubstituted pyrimidines with acyl radicals generated either from pyruvic acid-AgNO₃-(NH₄)₂S₂O₈ (method A) or from aldehyde-FeSO₄-t-BuOOH (method B) in aq. H₂SO₄, gave the corresponding 2, 6-disubstituted 4-acylpyrimidines. However, 4, 6-disubstituted pyrimidines gave 2-acetyl-and 2, 5-diacetyl-4, 6-disubstituted pyrimidines under the same conditions (methods A and B). Similarly, homolytic amidation of pyrimidines in which the 2- or 4-positions are free yielded pyrimidine-2- or -4-carboxamides.