Studies on Organic Fluorine Compounds. XXXI. Oxidative Coupling of Ketone Enolates and Trimethylsilyl Enol Ethers by Means of Cu(OTf)2

YOSHIRO KOBAYASHI; TAKEO TAGUCHI; TSUTOMU MORIKAWA; ETSUKO TOKUNO; SHOH SEKIGUCHI

doi:10.1248/cpb.28.262

Studies on Organic Fluorine Compounds. XXXI. Oxidative Coupling of Ketone Enolates and Trimethylsilyl Enol Ethers by Means of Cu(OTf)₂

小林義郎, 田口武夫, 森川勉, 得能悦子, 関口尚

著者情報

キーワード: trimethylsilyl enol ether

ジャーナルフリー

1980 年 28 巻 1 号 p. 262-267

DOI https://doi.org/10.1248/cpb.28.262

詳細

抄録

The oxidative coupling of ketone enolates and trimethylsilyl enol ethers by means of cupric trifluoromethanesulfonate [Cu(OTf)₂] is described in detail. 1, 4-Diketones were effectively prepared by treating lithium enolates with Cu(OTf)₂ in i-PrCN. 1, 3-Cyclopentanedione derivatives were synthesized through intramolecular coupling of 2, 4-pentanedione derivatives. Treatment of trimethylsilyl enol ethers with Cu(OTf)₂ in i-PrCN also afforded the corresponding coupling products.

責任著者(Corresponding author)

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