Nitrosation of Ethyl Carbamate : Isolation of Ethyl N-Ethyl-N-nitrosocarbamate

YUICHI KAWAZOE; HIDEO KOGA; KIYOSHI TATSUMI; TADAO HORIUCHI

doi:10.1248/cpb.28.3447

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363

Nitrosation of Ethyl Carbamate : Isolation of Ethyl N-Ethyl-N-nitrosocarbamate

YUICHI KAWAZOE, HIDEO KOGA, KIYOSHI TATSUMI, TADAO HORIUCHI

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Keywords: alkylating agent

JOURNAL FREE ACCESS

1980 Volume 28 Issue 11 Pages 3447-3448

DOI https://doi.org/10.1248/cpb.28.3447

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Abstract

A potent mutagen, ethyl N-ethyl-N-nitrosocarbamate, was isolated from the reaction of ethyl carbamate with NaNO₂. A possible reaction mechanism was proposed.

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